Cisplatin an anticancer compound contains
WebThe present disclosure relates generally to anti-cancer pharmaceuticals. More specifically, the disclosure is directed to gold complexes of Formula I with anti-cancer properties. The disclosure also provides a pharmaceutical composition comprising the complexes, a process of synthesizing the complexes and a method of treating cancer. The complexes of the … WebNeurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were …
Cisplatin an anticancer compound contains
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WebPlatinum compounds form DNA adducts, which ultimately result in activation of p53-dependent and p53-independent apoptosis.24 As monotherapy, cisplatin has anticancer activity comparable with that of other single agents, leading to response rates of approximately 15% and a median survival of 6 to 8 months. 21 In order to increase the … Cisplatin is a chemotherapy drug that contains the metal platinum. It stops or slows growth of cancer cells and other cells that grow rapidly by damaging their DNA. FDA Approved Yes FDA label information for this drug is available at DailyMed. Use in Cancer Cisplatin is approved to be used alone or with other drugs … See more Cisplatin is approved to be used alone or with other drugs to treat: 1. Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, such as surgery or radiation therapy. 2. … See more Definition from the NCI Drug Dictionary- Detailed scientific definition and other names for this drug. MedlinePlus Information on Cisplatin- A lay language summary of … See more Find Clinical Trials for Cisplatin- Check for trials from NCI's list of cancer clinical trials now accepting patients. See more
WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the bloodstream, it remains intact due the relatively high concentration of chloride ions (~100 mM). WebFeb 22, 2024 · Terpenoids are bioactive compounds with a variety of pharmacological activities, including anticancer activity. This review paper aimed to focus on the anticancer activities of certain terpenoids, including their molecular …
WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA and inducing apoptosis. Cisplatin is a small and remarkably simple molecule composed of one platinum atom linked to two amides and two chlorides. WebDespite the enormous importance of cisplatin as a chemotherapeutic agent, its application is impacted by dose-limiting side effects and lack of selectivity for cancer cells. Researchers can overcome these issues by taking advantage of the pro-drug nature of the platinum(IV) oxidation state, and by modifying the coordination sphere of the metal centre with …
Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi…
WebJan 28, 2024 · So, the anticancer properties of cisplatin arise from the substitution of the chlorine ligands with nucleophiles, such as DNA strand, hindering the replication of cancer cells. Interestingly, normal cells can manage DNA damage caused by cisplatin with the help of in-built repair mechanisms. 3.3. Mechanisms of Action dgraph ratel graphqlWebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. dgrasso cplaw1.comWebMetal-based anticancer chemotherapeutic agents Since the discovery of the cisplatin antitumor activity, great efforts have focused on the rational design of metal-based anticancer agents that can be potentially used in cancer chemotherapy. Over the last four decades, a large number of metal complexes have been extensively investigated and … dgr and the limits of victorian visionWebCisplatin 7. Bioinorganic Chemistry. The transition metals, also called the d-block elements, are found in groups 3-12 of the periodic table. These elements make the transition … cicely hunscherWebApr 6, 2024 · Complete answer: In cisplatin there is one atom of platinum, three molecules of ammonia and two atoms of Chlorine. Cisplatin is a coordination compound. … d g rallyWebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. … dgraph retalWebOct 28, 2024 · There have been reports confirming the role of apoptosis as an essential mode of action for several anti-tumour agents, such as alkylating agents including the widely used cisplatin and 1,3- bis (2-chloroethyl)-1-nitrosourea (BCNU) [ 22 ], ionising radiation [ 23 ], topoisomerase inhibitor etoposide, taxol [ 24 ], the tumour necrosis factor (TNF) … dgraph-io/dgraph