Klf4 macrophage

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August undefined, 2024

WebNov 18, 2024 · Indeed, accumulation of macrophages around apoptotic adipocytes (forming CLS), leads to an increase in macrophage and neutrophil recruitment to the liver, … WebMay 18, 2015 · SMC-specific conditional knockout of Krüppel-like factor 4 ( Klf4) resulted in reduced numbers of SMC-derived MSC- and macrophage-like cells, a marked reduction in lesion size, and increases in...

KLF4 - Wikipedia

WebJun 11, 2024 · KLF4 appears to regulate this transition to a macrophage-like phenotype. Collectively then, whereas KLF4 in myeloid-lineage cells appears to be atheroprotective, KLF4 in SMCs is proatherogenic. These results point to differential functions of KLF members in different cell types in pathology. WebMacrophages can be classified into many different types based on their phenotype versus their functional role in the plaque. One of the classical inflammatory macrophage phenotypes is named M1, which can be induced by a combination of interferon-γ (INF-γ) and toll-like receptor 4 (TLR4) ligand lipopolysaccharide in macrophages cultured in vitro. real christmas trees near swindon

KLF4 regulates autophagy in Mtb-infected macrophages.

WebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of immune checkpoints. Higher levels of CD8 + T cells and macrophage infiltration are associated with increased KLF4 expression in HCC TMA. WebKLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb. WebJan 1, 2024 · KLF4 is a bifunctional transcription factor, and its promotional and inhibitory functions in atherosclerosis depend on the target genes and target cells. KLF4 has a … real christmas trees belfast

CREB pathway links PGE2 signaling with macrophage polarization

Cholesterol-Induced Phenotypic Modulation of Smooth Muscle …

WebMay 30, 2024 · The early upregulation of KLF4 in Mtb-infected macrophages, suggests that Mtb infection possibly impacts post-translational mechanisms of regulation of KLF4 as well. A post-transcriptional mechanism of upregulation of KLF4 linked to the downregulation of cellular miR-145 has been reported during infection of keratinocytes with human ... WebJan 25, 2024 · In young macrophages, the core molecular clock maintains healthy immune responses through KLF4. In aged macrophages, KLF4 activity diminishes despite a … how to teach a budgie to talk how to teach a child assertiveness

"WebJun 4, 2015 · Macrophages are also derived from SMCs that undergo a phenotypic switch. Under the control of KLF4, the SMCs stop expressing marker proteins such as TAGLN, α-actin (ACTA2), and myosin heavy... " - Klf4 macrophage

Klf4 macrophage

Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

WebApr 13, 2024 · As an underlying anti-inflammatory factor, it has been reported that KLF4 can attenuate macrophages inflammation by inactivating NF-κB pathway and manage macrophages polarization, cells apoptosis and other biological activities [ 24 – 27 ]. WebApr 8, 2024 · The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci. 2011;68:3121–31. Article CAS PubMed Google Scholar

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WebAug 9, 2024 · Our previous study has shown that KLF4 SUMOylation plays an important role in macrophage M2 polarization. In the present study, small ubiquitin-like modifier (SUMO) … WebIn this regard, KLF4 has been shown to cooperate with STAT6 in promoting M2 macrophage polarization; deletion of the KLF4 gene in macrophages disrupts M2 function and increases proinflammatory gene expression . Moreover, the mouse KLF4 promoter contains CREB binding sites at −269 and −232 relative to the transcription start site.

WebDownload scientific diagram KLF4 regulates autophagy in Mtb-infected macrophages. (A, B) BMDMs or RAW264.7 (C,D) were transfected with control siRNA or Klf4 siRNA prior to infection with Mtb. WebKLF4 may promote inflammation by mediating NF-κB-dependent inflammatory pathway such as in macrophages, esophageal epithelium and in chemically-induced acute colitis in …

WebMacrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human … WebAug 9, 2024 · Macrophages are very important immune cells and play critical roles in tumour immunity. Macrophage subtypes can be divided into classical polarization (M1 macrophages) and alternative polarization (M2 macrophages) under different microenvironments. Krüppel-like factor 4 (KLF4) is an essential transcription factor for …

WebAug 14, 2024 · Macrophage polarization and infiltration to the tumor microenvironment (TME) is a critical determining factor for tumor progression. Macrophages are polarized …

WebOct 8, 2024 · The upregulation of macrophage makers is dependent on the transcription factor Klf4, but the exact mechanism for this activation of Klf4 has not previously been determined. 12 In this study, we demonstrate that cholesterol exposure activates all 3 pathways of the UPR and induces phenotypic switching primarily via the Perk-eIF2α-Atf4 … how to teach a child social skillsWebDec 10, 2024 · In contrast to PDGFR-β + cells, KLF4 reduction in α-smooth muscle actin (SMA) + cells non-cell autonomously exacerbates lung fibrosis by inducing macrophage accumulation and pro-fibrotic... how to teach a child independenceWebJun 13, 2011 · Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators … how to teach a child reading comprehensionWebApr 30, 2024 · As such, it is possible that kidney-derived CSF2 induces KLF4-dependent resident macrophage proliferation. Future studies will be needed to delineate the detailed mechanisms by which KLF4 regulates … real christmas trees philadelphia paWebApr 12, 2024 · Gain- and loss-of function study of KLF4 indicates that the DNMT1-mediated macrophage M1 activation is dependent on KLF4. Our data demonstrate a proatherogenic role for DNMT1 as a defining factor in macrophage inflammation both in vitro and in vivo. DNMT1 promotes macrophage M1 activation by suppressing KLF4 expression how to teach a child guitarWebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the … how to teach a child to play chessWebJul 23, 2024 · Background. Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc … how to teach a child basic multiplication